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Graphical contents list • CONTENTS LIST PDF (604 K) | |||
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Inhibition of the strand transfer step of HIV-1 integrase by non-natural dinucleotides • SHORT COMMUNICATION Guochen Chi, Nouri Neamati and Vasu Nair SummaryPlus | Full Text + Links | PDF (261 K) | |||
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Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation • SHORT COMMUNICATION Corey Hopkins, Kent Neuenschwander, Anthony Scotese, Sharon Jackson, Thaddeus Nieduzak, Henry Pauls, Guyan Liang, Keith Sides, Dona Cramer, Jennifer Cairns et al. SummaryPlus | Full Text + Links | PDF (358 K) | |||
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Computational comparison of microtubule-stabilising agents laulimalide and peloruside with taxol and colchicine • SHORT COMMUNICATION Oriol Pineda, Jaume Farràs, Laura Maccari, Fabrizio Manetti, Maurizio Botta and Jaume Vilarrasa SummaryPlus | Full Text + Links | PDF (483 K) | |||
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Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles • SHORT COMMUNICATION Chi B. Vu, Deborah Pan, Bo Peng, Li Sha, Gnanasambandam Kumaravel, Xiaowei Jin, Deepali Phadke, Thomas Engber, Carol Huang, Jennifer Reilly et al. SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists • SHORT COMMUNICATION Chi B. Vu, Pamela Shields, Bo Peng, Gnanasambandam Kumaravel, Xiaowei Jin, Deepali Phadke, Joy Wang, Thomas Engber, Eman Ayyub and Russell C. Petter SummaryPlus | Full Text + Links | PDF (265 K) | |||
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End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists • SHORT COMMUNICATION L.N. Koikov, F.H. Ebetino, J.C. Hayes, D. Cross-Doersen and J.J. Knittel SummaryPlus | Full Text + Links | PDF (267 K) | |||
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Modeling the binding affinities of β-secretase inhibitors: application to subsite specificity • SHORT COMMUNICATION Ramkumar Rajamani and Charles H. Reynolds SummaryPlus | Full Text + Links | PDF (282 K) | |||
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N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists • SHORT COMMUNICATION Ian Egle, Nancy Barriault, Michel Bordeleau, Jillian Drage, Laurence Dube, Jack Peragine, Lucy Mazzocco, Jalaj Arora, Keith Jarvie and Ashok Tehim SummaryPlus | Full Text + Links | PDF (258 K) | |||
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Design and synthesis of 3′-ureidoadenosine-5′-uronamides: effects of the 3′-ureido group on binding to the A3 adenosine receptor • SHORT COMMUNICATION Lak Shin Jeong, Myong Jung Kim, Hea Ok Kim, Zhan-Guo Gao, Soo-Kyung Kim, Kenneth A. Jacobson and Moon Woo Chun SummaryPlus | Full Text + Links | PDF (297 K) | |||
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New DNA binding ligands as a model of chromomycin A3 • SHORT COMMUNICATION Shuhei Imoto, Yoshinari Haruta, Kyouichi Watanabe and Shigeki Sasaki SummaryPlus | Full Text + Links | PDF (376 K) | |||
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Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors • SHORT COMMUNICATION Lin Yan, Jeffrey J. Hale, Christopher L. Lynch, Richard Budhu, Amy Gentry, Sander G. Mills, Richard Hajdu, Carol Ann Keohane, Mark J. Rosenbach, James A. Milligan et al. SummaryPlus | Full Text + Links | PDF (305 K) | |||
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Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor • SHORT COMMUNICATION Julie A. Heath, Mukund M. Mehrotra, Shannon Chi, Jin-Chen Yu, Athiwat Hutchaleelaha, Stanley J. Hollenbach, Neill A. Giese, Robert M. Scarborough and Anjali Pandey SummaryPlus | Full Text + Links | PDF (317 K) | |||
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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1 • SHORT COMMUNICATION Andrew J. Souers, Dariusz Wodka, Ju Gao, Jared C. Lewis, Anil Vasudevan, Robert Gentles, Sevan Brodjian, Brian Dayton, Christopher A. Ogiela, Dennis Fry et al. SummaryPlus | Full Text + Links | PDF (281 K) | |||
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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2 • SHORT COMMUNICATION Anil Vasudevan, Dariusz Wodka, Mary K. Verzal, Andrew J. Souers, Ju Gao, Sevan Brodjian, Dennis Fry, Brian Dayton, Kennan C. Marsh, Lisa E. Hernandez et al. SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3 • SHORT COMMUNICATION Andrew J. Souers, Dariusz Wodka, Ju Gao, Jared C. Lewis, Anil Vasudevan, Sevan Brodjian, Brian Dayton, Christopher A. Ogiela, Dennis Fry, Lisa E. Hernandez et al. SummaryPlus | Full Text + Links | PDF (268 K) | |||
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Unnatural base pairs between 2- and 6-substituted purines and 2-oxo(1H)pyridine for expansion of the genetic alphabet • SHORT COMMUNICATION Ichiro Hirao, Tsuyoshi Fujiwara, Michiko Kimoto and Shigeyuki Yokoyama SummaryPlus | Full Text + Links | PDF (269 K) | |||
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Discovery of orally active prostaglandin D2 receptor antagonists • SHORT COMMUNICATION Kazuhiko Torisu, Kaoru Kobayashi, Maki Iwahashi, Yoshihiko Nakai, Takahiro Onoda, Toshihiko Nagase, Isamu Sugimoto, Yutaka Okada, Ryoji Matsumoto, Fumio Nanbu et al. SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Potent and selective P2–P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1′, P1, and/or P3 substitutions • SHORT COMMUNICATION David G. Barrett, John G. Catalano, David N. Deaton, Anne M. Hassell, Stacey T. Long, Aaron B. Miller, Larry R. Miller, Lisa M. Shewchuk, Kevin J. Wells-Knecht, Derril H. Willard et al. SummaryPlus | Full Text + Links | PDF (341 K) | |||
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Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists • SHORT COMMUNICATION Jeremy J. Clemens, Michael D. Davis, Kevin R. Lynch and Timothy L. Macdonald SummaryPlus | Full Text + Links | PDF (350 K) | |||
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Pyrrolo[2,1-c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity • SHORT COMMUNICATION Ahmed Kamal, R. Ramu, G.B. Ramesh Khanna, Ajit Kumar Saxena, M. Shanmugavel and Renu Moti Pandita SummaryPlus | Full Text + Links | PDF (261 K) | |||
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A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors • SHORT COMMUNICATION Md. Jashim Uddin, P.N. Praveen Rao, Md. Abdur Rahim, Robert McDonald and Edward E. Knaus SummaryPlus | Full Text + Links | PDF (328 K) | |||
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The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors • SHORT COMMUNICATION L. Nathan Tumey, Bayard Huck, Elizabeth Gleason, Jianmin Wang, Daniel Silver, Kurt Brunden, Sherry Boozer, Stephen Rundlett, Bruce Sherf, Steven Murphy et al. SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer • SHORT COMMUNICATION Veeresa Gududuru, Eunju Hurh, Gangadhar G. Durgam, Seoung Soo Hong, Vineet M. Sardar, Huiping Xu, James T. Dalton and Duane D. Miller SummaryPlus | Full Text + Links | PDF (274 K) | |||
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7-Substituted 2-phenyl-benzofurans as ERβ selective ligands • SHORT COMMUNICATION Michael D. Collini, David H. Kaufman, Eric S. Manas, Heather A. Harris, Ruth A. Henderson, Zhang B. Xu, Rayomand J. Unwalla and Chris P. Miller SummaryPlus | Full Text + Links | PDF (297 K) | |||
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Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters • SHORT COMMUNICATION Karine Gingras, Hovsep Avedissian, Eryk Thouin, Véronique Boulanger, Charles Essagian, Lisa McKerracher and William D. Lubell SummaryPlus | Full Text + Links | PDF (361 K) | |||
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Synthesis and evaluation of novel oxazoline MMP inhibitors • SHORT COMMUNICATION Gregory R. Cook, Ethirajan Manivannan, Thane Underdahl, Viera Lukacova, Yufen Zhang and Stefan Balaz SummaryPlus | Full Text + Links | PDF (324 K) | |||
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Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P • SHORT COMMUNICATION Jacob S. Barnor, Yumihiko Endo, Yuichiro Habu, Naoko Miyano-Kurosaki, Michiko Kitano, Hirokazu Yamamoto and Hiroshi Takaku SummaryPlus | Full Text + Links | PDF (352 K) | |||
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The development of new bicyclic pyrazole-based cytokine synthesis inhibitors • SHORT COMMUNICATION Jennifer A. Townes, Adam Golebiowski, Michael P. Clark, Matthew J. Laufersweiler, Todd A. Brugel, Mark Sabat, Roger G. Bookland, Steve K. Laughlin, John C. VanRens, Biswanath De et al. SummaryPlus | Full Text + Links | PDF (313 K) | |||
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Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles • SHORT COMMUNICATION Sanath K. Meegalla, Dario Doller, DeYou Sha, Rich Soll, Nancy Wisnewski, Gary M. Silver and Dale Dhanoa SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Study on noncovalent complexes of cytotoxic protoberberine alkaloids with double-stranded DNA by using electrospray ionization mass spectrometry • SHORT COMMUNICATION Wen-Hua Chen, Chi-Leung Chan, Zongwei Cai, Guo-An Luo and Zhi-Hong Jiang SummaryPlus | Full Text + Links | PDF (556 K) | |||
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Synthesis, structural properties and insulin-enhancing potential of bis(quercetinato)oxovanadium(IV) conjugate • SHORT COMMUNICATION Ruchi Shukla, Vivek Barve, Subhash Padhye and Ramesh Bhonde SummaryPlus | Full Text + Links | PDF (290 K) | |||
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Synthesis and structure–activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5 • SHORT COMMUNICATION Martin W. Rowbottom, Fabio C. Tucci, Patrick J. Connors, Jr, Timothy D. Gross, Yun-Fei Zhu, Zhiqiang Guo, Manisha Moorjani, Oscar Acevedo, Lee Carter et al. SummaryPlus | Full Text + Links | PDF (305 K) | |||
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Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells • SHORT COMMUNICATION Christina Lorenz, Philipp Hadwiger, Matthias John, Hans-Peter Vornlocher and Carlo Unverzagt SummaryPlus | Full Text + Links | PDF (330 K) | |||
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Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate • SHORT COMMUNICATION Jerry M. Troutman, Kareem A.H. Chehade, Katarzyna Kiegiel, Douglas A. Andres and H. Peter Spielmann SummaryPlus | Full Text + Links | PDF (272 K) | |||
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Synthesis of dimeric acridine derived antivirals • SHORT COMMUNICATION René Csuk, Alexander Barthel, Torsten Brezesinski and Christian Raschke SummaryPlus | Full Text + Links | PDF (248 K) | |||
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Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator • SHORT COMMUNICATION J.R. Falck, Deb Barma, Suchismita Mohapatra, A. Bandyopadhyay, Komandla Malla Reddy, Jianjun Qi and William Campbell SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Synthesis of enantiomerically pure D-FDOC, an anti-HIV agent • SHORT COMMUNICATION Shuli Mao, Martin Bouygues, Christopher Welch, Mirlinda Biba, Jen Chilenski, Raymond F. Schinazi and Dennis C. Liotta SummaryPlus | Full Text + Links | PDF (296 K) | |||
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Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the β-receptor blocking drug propranolol • SHORT COMMUNICATION Michael Decker, Andreas König, Erika Glusa and Jochen Lehmann SummaryPlus | Full Text + Links | PDF (269 K) | |||
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Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase • SHORT COMMUNICATION Erwin P. Schreiner and Andreas Billich SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Synthesis of ether analogues derived from HUN-7293 and evaluation as inhibitors of VCAM-1 expression • SHORT COMMUNICATION Erwin P. Schreiner, Michael Kern, Andrea Steck and Carolyn A. Foster SummaryPlus | Full Text + Links | PDF (275 K) | |||
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P4 and P1′ optimization of bicycloproline P2 bearing tetrapeptidyl α-ketoamides as HCV protease inhibitors • SHORT COMMUNICATION Yvonne Yip, Frantz Victor, Jason Lamar, Robert Johnson, Q. May Wang, John I. Glass, Nathan Yumibe, Mark Wakulchik, John Munroe and Shu-Hui Chen SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Pyridazine derivatives and related compounds. Part 13: Synthesis and antimicrobial activity of some pyridazino[3′,4′:3,4]pyrazolo[5,1-c]-1,2,4-triazines • SHORT COMMUNICATION Ali Deeb, Fatma El-Mariah and Mona Hosny SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Editorial board • EDITORIAL BOARD PDF (390 K) | |||
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Contributors to this issue • INDEX PDF (188 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (70 K) | |||
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